2024 Henri Boulard Winner Dr. G. Alle

3 Questions to Dr. Gbenga Alle

What is the relationship between your project and Microbiota?

The over-reliance on Metronidazole (an antibiotic and antiprotozoal) commonly used agent for the treatment of acute diarrhea in Nigeria, does not only contribute to antibiotic resistance but also have significant effects on the gut Microbiota. While it is effective against anaerobic bacteria, it also eliminates beneficial bacteria disrupting the normalcy of the gut Microbiota. This could cause;

• A reduction in the diversity of the gut microbiota,
• Overgrowth of opportunistic pathogens and
• Potential long-term impact like chronic gastrointestinal conditions such as Irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and increased susceptibility to gastrointestinal infections.

How your project can reduce the inappropriate use of metronidazole in the management of acute diarrhea in Nigeria?

Healthcare Professionals and the general public across various health centres in Lagos (The most populous state in Nigeria) will be educated on the dangers of metronidazole misuse. The project will emphasize safer and more effective alternatives, such as probiotics and necessary dietary adjustments, for preventing and managing acute diarrhea. The initiative will be based on evidence-based guidelines for diagnosing and treating acute diarrhea, aligned with standards established by international organizations like the World Health Organization (WHO), the World Gastroenterology Organization (WGO), and the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). By raising this awareness, the campaigns will reduce the risk of antibiotic resistance, ensuring that metronidazole remains effective for critical medical needs in the future.

How the Henri Boulard Award will help your team to perform your project?

A heartfelt appreciation to Biocodex Microbiota Foundation for spearheading this invaluable initiative. With their support, Henri Boulard Award presents an exceptional opportunity to tackle the widespread misuse of metronidazole in Nigeria which has become a significant threat to gut health. A more effective and sustainable approach to managing acute diarrhea will be promoted which will overall reduce preventable deaths across the country.