Biocodex - Micro-Report

The neurodegeneration that occurs in Alzheimer patients

is partly caused by abnormal accumulation of a protein

called amyloid beta Aβ peptides around the nerve cells

This accumulation of proteins leads to the formation of

amyloid plaques also known as senile plaques

WHICH PATHOLOGIES

COULD BE CONCERNED?

AUTISM AND ATTENTION DEFICIT DISORDERS

(19)

30 to 50% of patients with an ASD (Autism Spectrum

Disorder) have digestive problems such as abdominal

pain, diarrhea or constipation

Many patients with an ASD have increased intestinal

permeability, gut inflammation and digestive problems

associated with exacerbated stress response.

In some clinical trials involving fecal microbiota

transplantation, reduced digestive symptoms were

accompanied by improved behavior.

ALZHEIMER’S DISEASE

(20)

A neurodegenerative disease associated with memory

loss, speech and comprehension difficulties, and

attention and concentration problems, Alzheimer’s

disease affects more than 35 million people worldwide.

Certain proteins produced by the bacteria in our

intestinal flora might increase our likelihood of

developing the disease. On the contrary, other bacteria

are thought to offer protection, by slowing down the

formation of amyloid plaques. Significant research is

being channeled into this area.

FECAL MICROBIOTA

TRANSPLANTATION FMT

A PROMISING APPROACH

This novel therapy consists of transferring fecal

microbiota from a healthy donor to the patient

FMT can be given through a colonoscope or

nasogastric tube or orally in capsule form

Several clinical trials are underway to assess

the impact of FMT on the evolution of chronic

andor very severe diseases

Under study…

The link between the existence of intestinal

dysbiosis and other disorders or diseases is

currently a hot research topic. Studies are

underway concerning Parkinson’s disease,

anxiety, depression, bipolar disorder and

schizophrenia, for example.

WHAT TREATMENTS ARE AVAILABLE

That’s the number of pathways

involved in gut-brain communication:

neural, endocrine, immune and

metabolic.

A KEY FIGURE

WHAT ARE

AMYLOID PLAQUES